---
slug: whats-new
summary: "A running log of new articles, edits, and structural changes to Human Longevity and Performance Patterns."
---

# What's New

Recent changes to Human Longevity and Performance Patterns.

## 2026-06-25

### What's New
- **New article:** [Alcohol Intake](alcohol-intake.md) — why the "glass a day is good for your heart" story collapsed, what the evidence now says about cancer, sleep, and mortality, and how to grade alcohol as an exposure rather than a longevity protocol.
- **New article:** [Vitamin D Supplementation for Healthspan](vitamin-d-supplementation.md) — why the largest trials nulled the headline endpoints in replete adults, what the live subgroup and telomere signals do and don't show, and where deficiency correction still earns the bottle.
- **New article:** [Mitochondrial Therapeutics for Healthspan](mitochondrial-therapeutics.md) — how to read elamipretide's rare-disease approval, aged-animal signals, and early human pilots without mistaking a mechanism story for proved healthspan benefit.
- **Improved:** [Age- and Risk-Appropriate Cancer Screening](cancer-screening.md) — tighter prose for clarity and concision.
- **Improved:** [Alcohol Intake](alcohol-intake.md) — clearer evidence prose around the NASEM-vs-ICCPUD split and the end of the simple cardioprotection story.
- **Improved:** [Vitamin D Supplementation for Healthspan](vitamin-d-supplementation.md) — sharper opening language with the evidence tiering and medical boundary preserved.

### Metrics
- Total articles: 102
- Coverage: 102 of 104 proposed concepts written (98%)
- Articles edited since last checkpoint: 3

## 2026-06-20

### What's New
- **New article:** [Urine Albumin-Creatinine Ratio (UACR) Screening](uacr-screening.md) — a low-cost diagnostic pattern that pairs urine albumin with eGFR to detect kidney-filter leakage and sharpen CKM risk interpretation without turning one urine result into a self-treatment plan.
- **New article:** [Vision Correction and Cataract Care](vision-care.md) — a sensory-access pattern that treats corrected vision and indicated cataract care as functional healthspan maintenance while keeping cognitive-risk claims observational and bounded.
- **New article:** [Age- and Risk-Appropriate Cancer Screening](cancer-screening.md) — the standard, guideline-graded screening ledger (colorectal, breast, cervical, lung, prostate) that premium cancer-detection products sit behind rather than replace.
- **Improved:** [Dental and Periodontal Maintenance](dental-periodontal-maintenance.md) — easier-to-scan risk-ledger and record-keeping guidance, with the article's evidence boundary around oral-systemic claims preserved.

### Metrics
- Total articles: 99
- Coverage: 99 of 101 proposed concepts written (98%)
- Articles edited since last checkpoint: 3

## 2026-06-18

### What's New
- **New article:** [Partial Epigenetic Reprogramming](partial-epigenetic-reprogramming.md) — a frontier concept that separates transient cellular reprogramming's cell and animal evidence from unproved healthy-longevity claims and future medical-tourism risk.
- **New article:** [Dental and Periodontal Maintenance](dental-periodontal-maintenance.md) — a routine-prevention pattern that places oral health and periodontal care on the healthspan map without overstating oral-systemic evidence.
- **Improved:** [Adult Immunization as Healthspan Preservation](adult-immunization.md) — current RSV eligibility guidance and a clearer vaccine-record review flow.
- **Improved:** [Partial Epigenetic Reprogramming](partial-epigenetic-reprogramming.md) — the first disease-specific human safety-trial milestone for ER-100, while preserving the boundary that partial reprogramming is not a proved healthy-longevity intervention.
- **Improved:** [Intravenous NAD+ and Oral NAD+ Precursors](nad-precursor-protocols.md) — sharper IV-evidence caveats and a cleaner split between commercial-clinic tolerability data and longevity outcome claims.
- **Structural:** Section landing pages now link newly added longevity, biomarker, nutrition, and clinical-pharmacology entries from their section overviews.

### Metrics
- Total articles: 96
- Coverage: 96 of 98 proposed concepts written (98%)
- Articles edited since last checkpoint: 3

## 2026-06-16

### What's New
- **New article:** [Home Blood Pressure Monitoring](blood-pressure-monitoring.md) — a low-cost pattern for standardized out-of-office blood pressure measurement that separates real pressure exposure from clinic artifact, technique error, and daily noise.
- **New article:** [Taurine and Healthy Aging](taurine-healthy-aging.md) — a food-first, endpoint-bound pattern that separates taurine's animal geroscience signal from the 2025 biomarker contradiction and the absence of human healthy-lifespan outcome data.
- **New article:** [Adult Immunization as Healthspan Preservation](adult-immunization.md) — a clinical-pharmacology pattern that treats adult vaccination as evidence-backed prevention and keeps vaccine-specific outcomes separate from broad healthy-lifespan claims.
- **Improved:** [Cardiovascular-Kidney-Metabolic (CKM) Syndrome](ckm-syndrome.md) — clearer staging language, a stronger boundary against self-diagnosis, and current AHA nuance that CKM stages can progress or regress as risk factors change.
- **Improved:** [Home Blood Pressure Monitoring](blood-pressure-monitoring.md) — clearer white-coat and masked-pattern language, a tighter threshold explanation, and a stronger boundary between home readings and clinician-owned treatment decisions.
- **Improved:** [Taurine and Healthy Aging](taurine-healthy-aging.md) — cleaner evidence-revision language, a stronger boundary around supplement testing, and tighter framing of the 2025 biomarker contradiction.

### Metrics
- Total articles: 94
- Coverage: 94 of 99 proposed concepts written (95%)
- Articles edited since last checkpoint: 3

## 2026-06-15

### What's New
- **New article:** [Cardiovascular-Kidney-Metabolic (CKM) Syndrome](ckm-syndrome.md) — a guideline-backed concept that connects metabolic risk, kidney function, and cardiovascular disease into one staged risk map without turning CKM into a consumer identity or self-managed protocol.
- **New article:** [Intravenous NAD+ and Oral NAD+ Precursors](nad-precursor-protocols.md) — an evidence-graded guide that separates oral NR/NMN from IV NAD+ protocols, updates NMN's regulatory status, and keeps NAD+ claims bounded to measured endpoints.
- **New article:** [Spermidine Supplementation](spermidine-supplementation.md) — a food-first and endpoint-bound pattern that separates spermidine's autophagy mechanism and dietary association from the negative low-dose cognition RCT and pending higher-dose cardiovascular research.
- **Improved:** [Stem Cell Therapy (Allogeneic MSC, Autologous SVF)](stem-cell-therapy.md) — clearer opening, current FDA and court regulatory framing, and tighter language separating disease-specific evidence from unproven healthy-longevity claims.
- **Improved:** [Sleep Consistency](sleep-consistency.md) — current 2025-2026 cardiovascular evidence and clearer timing nuance around wake time, bedtime, and sleep-midpoint regularity.
- **Improved:** [Circadian Light Hygiene](circadian-light-hygiene.md) — a clearer whole-day light-dose opening and a current 2026 sensor-based field study framed as weak observational support.
- **Improved:** [Spermidine Supplementation](spermidine-supplementation.md) — tighter prose, clearer endpoint discipline, and a sharper distinction between food-source exposure, a negative low-dose cognition RCT, and pending higher-dose cardiovascular research.

### Metrics
- Total articles: 91
- Coverage: 91 of 96 proposed concepts written (95%)
- Articles edited since last checkpoint: 4

## 2026-06-14

### What's New
- **Improved:** [Polarized Training Distribution](polarized-training-distribution.md) — removes catalog-facing prose, clarifies 80/20 as a recoverable weekly shape rather than exact arithmetic, and corrects evidence-section citation-year drift.
- **Improved:** [Urolithin A and Mitophagy Supplementation](urolithin-mitophagy.md) — corrects trial details, adds a current athlete-evidence caveat, and tightens endpoint-discipline prose.
- **Improved:** [Mechanism-Pumping](mechanism-pumping.md) — adds a clearer opening explanation of the coined term and tighter evidence-boundary prose.
- **Improved:** [Exosomes](exosomes.md) — distinguishes research terminology from clinic marketing more clearly and updates FDA enforcement context through May 2026.
- **Improved:** [Gene Therapy Tourism](gene-therapy-tourism.md) — updates Minicircle registry details, operator-evidence framing, and official/operator sources around investigational FST-344 access abroad.
- **Improved:** [Stability and Mobility Practice](stability-mobility-practice.md) — adds a clearer opening on-ramp and cleaner boundaries around movement-capacity checks, pain, screens, and fall-prevention evidence.
- **Improved:** [Photobiomodulation (Red and Near-Infrared Light)](red-nir-photobiomodulation.md) — adds a clearer opening on-ramp, current transcranial PBM trial details, and tighter FDA device-clearance framing.

### Metrics
- Total articles: 88
- Coverage: 88 of 95 proposed concepts written (93%)
- Articles edited since last checkpoint: 7

## 2026-06-10

### What's New
- **Improved:** [Hearing Correction as Cognitive-Reserve Support](hearing-cognitive-reserve.md) — tighter, more readable prose throughout.
- **Improved:** [Cold Water Immersion](cold-water-immersion.md) — sharper framing of the gap between cold exposure's strong sensation and its limited long-term evidence.
- **Improved:** [Inflammaging](inflammaging.md) — tighter opening and clearer clinical-mechanism passages.
- **Improved:** [Creatine Monohydrate](creatine-monohydrate.md) — more concrete prose with no change to any evidence or dosing claim.
- **Improved:** [Fasting-Mimicking Diet](fasting-mimicking-diet.md) — tighter prose and a sharper biological-age caveat, with evidence, protocol, and contraindications unchanged.
- **Improved:** [Hypoxic Conditioning](hypoxic-conditioning.md) — less repetitive prose and clearer phrasing throughout.
- **Improved:** [GlyNAC (Glycine + N-Acetylcysteine)](glynac.md) — clearer, less-hedged dosing description.
- **Improved:** [MIND Diet Pattern](mind-diet-pattern.md) — sharper prose on what the diet does and does not prove for cognitive aging.
- **Improved:** [Polyphenol Intake](polyphenol-intake.md) — a sharper opening that lands the food-first thesis, with tighter prose throughout.

### Metrics
- Total articles: 88
- Coverage: 88 of 92 proposed concepts written (96%)
- Articles edited since last checkpoint: 9

## 2026-06-07

### What's New
- **New article:** [Gene Therapy Tourism](gene-therapy-tourism.md) — a frontier guide to unapproved longevity gene or plasmid therapies that separates plausible animal and early human signals from proof, regulatory approval, and safe medical-tourism governance.
- **New article:** [GlyNAC (Glycine + N-Acetylcysteine)](glynac.md) — a high-dose glutathione-precursor protocol framed as small human proof-of-concept, not proven lifespan, disease-event, or healthy-longevity therapy.
- **Improved:** [Multi-Cancer Early Detection (MCED)](mced-screening.md) — redrafted with a clearer opening and a tighter evidence boundary around disputed screening benefit, FDA status, and clinician-owned follow-up.
- **Improved:** [GDF15 as a Biomarker of Biological Aging](gdf15-aging-biomarker.md) — clarifies how to read GDF15 as a slow cellular-stress risk index, not a marker to lower, with sharper metformin and acute-illness caveats.
- **Improved:** [Single-Biomarker Tunnel Vision](single-biomarker-tunnel.md) — adds a clearer opening and tighter guidance on keeping biomarker data inside its validated decision boundary.
- **Improved:** [Concierge Longevity Primary Care](attia-concierge-care.md) — adds a clearer opening, tighter evidence boundaries, and primary Attia/Early Medical sourcing for the 2026 practice context.
- **Improved:** [Low-Dose Tadalafil](tadalafil-longevity-use.md) — separates on-label vascular and urologic evidence from unproven dementia-prevention, lifespan, and healthy-adult longevity claims.
- **Improved:** [Calcium Alpha-Ketoglutarate (Ca-AKG / Rejuvant)](calcium-alpha-ketoglutarate.md) — tightens clinician-boundary language and current trial-status wording while preserving the central evidence message.

### Metrics
- Total articles: 88
- Coverage: 88 of 92 proposed concepts written (96%)
- Articles edited since last checkpoint: 6

## 2026-05-27

### What's New

A sweep across twenty-three foundational and measurement entries reshaped each one to lead with its core vocabulary, separating the raw signal or mechanism from the evidence, the interpretation limits, and the medical and legal boundary. The intent is the same throughout: make each entry read as a reference you reason with, not a protocol you follow.

- **Improved:** [Healthspan vs. Lifespan](healthspan-lifespan.md) — separates survival, healthy-life years, HALE, functional endpoints, surrogate markers, and definitional limits.
- **Improved:** [Evidence Tiers](evidence-tiers.md) — separates claim shape, endpoint specificity, the evidence hierarchy, surrogate limits, and commercial-claim boundaries.
- **Improved:** [Hallmarks of Aging](aging-hallmarks.md) — now reads as mechanism vocabulary rather than a protocol, with a clearer boundary between hallmark biology and human outcome evidence.
- **Improved:** [Biological Age](biological-age.md) — separates model targets, measurement frames, evidence strength, score interpretation, and surrogate-endpoint limits.
- **Improved:** [Pace of Aging](aging-pace.md) — separates rate measurement, cohort validation, commercial-report interpretation, trial-endpoint use, and intervention-proof limits.
- **Improved:** [Frailty Index](frailty-index.md) — separates deficit scoring, whole-person reserve, measurement construction, evidence strength, setting transfer, and self-scoring boundaries.
- **Improved:** [Metabolic Flexibility](metabolic-flexibility.md) — separates fuel-switching definition, measurement boundaries, consumer-score limits, evidence strength, and clinical-advice boundaries.
- **Improved:** [Hormesis](hormesis.md) — separates the adaptive-stress definition, dose boundary, recovery signal, evidence strength, and the limits of mechanism-based claims.
- **Improved:** [The Longevity Pyramid](longevity-pyramid.md) — separates the framework definition, recognition questions, evidence limits, escalation boundaries, and the medical and legal boundary.
- **Improved:** [Lifestyle Theater](lifestyle-theater.md) — now carries the book's standard medical and legal boundary for reader-facing health reference entries.
- **Improved:** [Exercise-Induced Hormesis](exercise-induced-hormesis.md) — separates the adaptive-stress definition, recovery recognition, antioxidant-signal caveats, evidence strength, and the medical and legal boundary.
- **Improved:** [Heat Shock Proteins](heat-shock-proteins.md) — separates the HSP definition, claim-recognition questions, mechanism evidence, caveats, and the medical and legal boundary.
- **Improved:** [Advanced Glycation End Products](glycation-end-products.md) — separates AGE chemistry, recognition signals, evidence strength, measurement caveats, and the medical and legal boundary.
- **Improved:** [Grip Strength as Mortality Biomarker](grip-strength-mortality.md) — separates the measurement definition, interpretation limits, evidence strength, causality caveats, and the medical and legal boundary.
- **Improved:** [VO₂max](vo2max.md) — separates the measurement definition, interpretation limits, evidence strength, causality caveats, and the medical and legal boundary.
- **Improved:** [Resting Heart Rate and HRV](resting-hr-hrv.md) — separates raw autonomic signals from wearable recovery scores and clarifies how to read trends without treating them as diagnoses.
- **Improved:** [Sleep Architecture](sleep-architecture.md) — separates the sleep-stage definition, measurement hierarchy, wearable-stage limits, evidence strength, caveats, and the medical and legal boundary.
- **Improved:** [Caffeine Half-Life and Adenosine](caffeine-adenosine-cycle.md) — separates caffeine clearance, sleep-pressure recognition, dose-and-timing evidence, caveats, and the medical and legal boundary.
- **Improved:** [Cognitive Reserve](cognitive-reserve.md) — separates reserve definitions, proxy interpretation, observational evidence, caveats, and the diagnosis boundary.
- **Improved:** [Purpose (Ikigai-class) as Longevity Factor](ikigai-longevity-factor.md) — separates the measured purpose construct, observational evidence, behavior pathways, cultural caveats, and mental-health boundaries.
- **Improved:** [Metformin and the TAME Frame](metformin-tame-frame.md) — separates the diabetes evidence, the geroscience trial frame, off-label longevity use, and the still-unproven healthy-adult outcome claim.
- **Improved:** [The Longevity Clinic](longevity-clinic.md) — separates the clinic wrapper from the evidence, regulation, incentives, and clinical accountability inside it.
- **Improved:** [Medical Tourism for Longevity](longevity-medical-tourism.md) — separates jurisdictional access from evidence, product identity, facility governance, travel risk, records, and post-return care.

### Metrics
- Total articles: 86
- Coverage: 86 of 93 proposed concepts written (92%)
- Articles edited since last checkpoint: 23

## 2026-05-22

### What's New
- **New article:** [Calcium Alpha-Ketoglutarate (Ca-AKG / Rejuvant)](calcium-alpha-ketoglutarate.md) — a sober guide to the supplement category's mouse evidence, uncontrolled methylation-clock claim, and still-pending human RCTs.
- **New article:** [Exosomes](exosomes.md) — a product-specific guide to extracellular-vesicle therapy, FDA's unapproved-product boundary, and why disease-specific EV trials do not yet prove a healthy-longevity intervention.
- **Improved:** [Pace of Aging](aging-pace.md) — clearer opening that explains the state-versus-rate distinction and sharper guidance on why DunedinPACE-style movement is a risk signal, not proof that an intervention added healthy years.
- **Improved:** [Peptide Therapeutics](peptide-therapeutics.md) — tighter molecule-by-molecule framing, clearer regulatory language around the April 2026 FDA compounding update, and cleaner examples for BPC-157/TB-500 and CJC-1295/ipamorelin.
- **Improved:** [Hormesis](hormesis.md) — clearer opening and sharper dose-recovery framing that separates useful adaptive stress from unmanaged load with a mechanism story attached.
- **Improved:** [The Longevity Pyramid](longevity-pyramid.md) — clearer opening and sharper order-of-operations framing that keeps frontier interventions, diagnostics, and lifestyle work in evidence-tier context.
- **Structural:** Related Articles navigation across the clinical ecosystem now has reciprocal links from clinic, diagnostic, pharmacology, frontier, evidence-tier, and antipattern entries.

### Metrics
- Total articles: 86
- Coverage: 86 of 91 proposed concepts written (95%)
- Articles edited since last checkpoint: 4 (plus 1 structural navigation improvement)

## 2026-05-16

### What's New
- **Improved:** [Hyperbaric Oxygen Therapy (HBOT)](hyperbaric-oxygen-therapy.md) — tighter prose and cleaner rhythm across the regenerative-frontier entry, with a banned-vocab fix in the Hype Check admonish and a sharper split lede; named-protocol details and evidence-tier discipline preserved.
- **New article:** [GDF15 as a Biomarker of Biological Aging](gdf15-aging-biomarker.md) — a Biomarkers and Diagnostics pattern that separates the protein's strong observational age-and-mortality signal from the absent intervention RCT base, names the metformin elevation and severe-acute-illness confounds explicitly, and frames disciplined use as a slow-moving cellular-stress index read alongside hsCRP, ApoB, kidney function, and body composition.
- **Improved:** [Lp(a) Screening](lpa-screening.md) — replaced a textbook negative-parallelism construction in the Problem section with a less symmetrical mistake-pair, traded eighteen hedged "can / usually / may" constructions across Forces, Solution, Evidence, How It Plays Out, and Consequences for declarative verbs where the underlying claim was strong enough, compressed two demonstrative-pronoun "That" tics, and replaced the "lipid panel as one blob" colloquialism with the book's collegial-formal register.
- **Improved:** [Full-Body MRI Screening](full-body-mri.md) — rewrote the passive-progressive opener to name the actor (commercial clinics, not the abstract scan), tightened the Evidence section's ACR paragraph into clean declarative sentences, replaced a worn cliché with a more specific framing, and dropped two scan-as-agent personifications in the Consequences section.
- **Improved:** [DEXA Body Composition](dexa-body-composition.md) — broke the italic lede into a two-sentence thesis-plus-condition pair so the acronym-title accessibility gate reads cleanly, tightened the gerund-form Context chain into concrete noun cases, and traded fifteen hedged "can / may" constructions across Evidence, How It Plays Out, and Consequences for declarative verbs.
- **Improved:** [Sleep Tracking Anxiety](sleep-tracking-anxiety.md) — surgical pass on a substantively-correct draft that tightened the opening, sharpened the antipattern's failure mode, and preserved every cross-reference to the surrounding sleep-circadian entries.
- **Improved:** [Coronary CT Angiography](coronary-ct-angiography.md) — tightened the lede into a thesis-plus-clarification pair, broke parallel-structure repetition in the Forces list, sharpened the Solution and Evidence sections to read as decision-rule guidance, and replaced several copula-heavy "can / may" constructions with the more declarative verbs the curator's calmly skeptical register asks for.
- **New article:** [Polarized Training Distribution](polarized-training-distribution.md) — what the 80/20 weekly architecture is, where it comes from (Seiler's Norwegian-athlete training logs), what the head-to-head trials actually show against threshold and pyramidal distributions, and how to assemble Zone 2 and VO₂max intervals into a recoverable week without drifting into the threshold middle zone.
- **Improved:** [Social Connection as Longevity Intervention](social-connection-longevity.md) — tightened the italic lede into a thesis-plus-contrast pair, sharpened the Problem section's middle paragraph by replacing an abstract "make the system brittle" with a concrete "is fragile," compressed two restatement paragraphs in the Consequences section, and recast a stilted line about an older adult illustrating the medical edge.
- **New article:** [Inflammaging](inflammaging.md) — what the chronic low-grade inflammatory state of aging actually is, how to read hsCRP and IL-6 without being fooled by a recent illness, what IgG-glycan tests like GlycanAge add and what they don't, and why no current intervention has been shown to lower a composite inflammaging score and improve a clinical endpoint.
- **Improved:** [Therapeutic Plasma Exchange and Plasma Dilution](plasma-exchange-dilution.md) — tightened the lede, broke up overlong enumerative sentences, replaced chained passive constructions with active prose, and sharpened the contrast between TPE/plasma dilution and young-donor plasma infusion so the evidence stack and the candidate-vs-non-candidate decision read cleanly.
- **Improved:** [Caloric Restriction](caloric-restriction.md) — tightened the lede, sharpened the Wisconsin-vs-NIA primate framing, and re-grounded the How It Plays Out scenarios with named ages and specific deficits so a reader can see whose problem the intervention actually solves.
- **New article:** [Urolithin A and Mitophagy Supplementation](urolithin-mitophagy.md) — what the JAMA Network Open older-adult trial and the Nature Aging immune-aging trial actually showed, why the supplement marketing outruns the clinical evidence, and how to run a bounded 12-to-16-week trial with a defined stopping rule.
- **Improved:** [Personality-Brand Capture](personality-brand-capture.md) — new opening paragraph that names the coinage's specific failure mode plainly, a tighter Context section that sharpens the four-question audit checklist, and cleaner phrasings throughout Problem, Solution, and Consequences that vary the "capture" repetition and land the closing rule — *learn from personalities; do not belong to their protocols* — with less throat-clearing along the way.
- **Improved:** [Testosterone Replacement Therapy (TRT)](testosterone-replacement-therapy.md) — tighter opening that distinguishes replacement medicine from performance pharmacology, sharper symptom-and-cause framing, and a Liabilities paragraph that lands a useful clinical point about why a man might feel worse on TRT.
- **Improved:** [Senolytics (Dasatinib + Quercetin, Fisetin)](senolytic-cocktails.md) — clearer opening that explains where the term *senolytic* comes from (Latin *senex* + Greek *-lytic*), plus tightened prose throughout.
- **Improved:** [Coronary Artery Calcium Scoring](coronary-calcium-scoring.md) — sharper Context lede, a multi-clause Evidence sentence broken into four for scannability, a present-tense USPSTF paragraph, and "the repeat-scan cascade is Biomarker Treadmill in slow motion."
- **Improved:** [Metformin and the TAME Frame](metformin-tame-frame.md) — sharper lede on why the trial frame outlasts the drug, cleaner three-routes paragraph, a tighter AFAR / TAME-status block, and small grammar fixes throughout.
- **Improved:** [Comprehensive Annual Bloodwork](comprehensive-annual-bloodwork.md) — sharpened thesis paragraph, fixed an awkward aside about blood pressure, replaced one editorial phrase, trimmed the "what the panel misses" list with a concrete closer about risk factors that don't show up in serum.
- **Improved:** [Wellness-Influencer SEO Listicle](wellness-seo-listicle.md) — split a 71-word italic lede into two cleaner sentences, broke the suspicious symmetry of five "It implies X..." paragraphs, varied the "...so X" rhythm in the Forces bullets, and tightened a muddled Evidence phrasing.
- **Improved:** [Medical Tourism Quality Roulette](medical-tourism-roulette.md) — new orientation paragraph that explains the "roulette" name and a tighter pass through the Context, Problem, Forces, and Consequences sections.
- **Improved:** [Continuous Glucose Monitoring (Non-Diabetic)](nondiabetic-cgm.md) — tighter prose with more natural contractions and a cleaner reading of the Hjort 2024 finding that glycemic variability is higher in people with prediabetes than in those without diabetes.
- **Improved:** [Hallmarks of Aging](aging-hallmarks.md) — short origin paragraph naming the 2013 López-Otín paper that introduced the framework, the three criteria a process must clear to count as a hallmark, and the 9 → 12 expansion across the 2013 and 2023 papers.
- **Improved:** [Biological Age](biological-age.md) — tighter prose, plainer verbs, and a clearer distinction between what an epigenetic clock measures and what it doesn't.
- **Improved:** [Caffeine Half-Life and Adenosine](caffeine-adenosine-cycle.md) — replaced an awkward half-life restatement with a concrete "quarter-dose at 10–12 hours" claim, tightened several AI-cadence sentences in the Evidence section, and recast the lede to read more directly.
- **Improved:** [Female HRT/BHRT](female-hrt-bhrt.md) — tightened the lede, cut two "the reader" meta hedges, replaced a repeated "is not the same claim" tic with concrete reframings, and compressed several copula-routed sentences; preserved every citation, date, and regulatory marker verbatim.
- **Improved:** [Blueprint Protocol (Bryan Johnson)](blueprint-bryan-johnson.md) — replaced the banned "straightforward" tell, cut soft openers and filler hedges, broke a tricolon rhythm in the Consequences section, and reframed two awkward causal-attribution sentences.
- **Improved:** [The Longevity Clinic](longevity-clinic.md) — tightened the lede, recast a 62-word Context run-on into two cleaner sentences, replaced a double-negative hedge stack with a cleaner two-clause statement, and varied a suspicious tricolon in the Consequences section.
- **Improved:** [Protein Intake for Sarcopenia Prevention](sarcopenia-protein-intake.md) — plainer opening that defines sarcopenia in everyday terms and pairs the protein side with the resistance-training side that has to ride alongside it.
- **Improved:** [Time-Restricted Eating](time-restricted-eating.md) — tighter prose in the Solution and Evidence sections, with a sharper line between fasting structure and fasting identity.
- **Improved:** [Rapamycin Cargo-Culting](rapamycin-cargo-culting.md) — plain opening that names where the "cargo cult" image comes from (Feynman's 1974 Caltech address and the postwar Melanesian scenes he borrowed it from) and what that has to do with copying the visible form of a rapamycin protocol without the supervised oversight.
- **Improved:** [GLP-1 Receptor Agonists for Longevity-Adjacent Outcomes](glp1-longevity-outcomes.md) — plain opening that expands the acronym (glucagon-like peptide-1, a gut hormone released after meals), says what the drug class does, and places tirzepatide inside the same decision frame.
- **Improved:** [Rapamycin Off-Label Longevity Dosing](rapamycin-longevity-dosing.md) — plain opening that explains where the drug's name comes from — a 1964 soil sample from Rapa Nui (Easter Island), the bacterium that produced it, Ayerst Laboratories' early-1970s isolation, and the later renaming to sirolimus.
- **Improved:** [Aspirational Stack Theater](aspirational-stack-theater.md) — plain opening that names the everyday scene (a published longevity stack that has quietly stopped matching the lived practice) and sources the name to Erving Goffman's front-stage / back-stage distinction.
- **Improved:** [VO₂max-Targeted Intervals](vo2max-targeted-intervals.md) — plain opening that expands the acronym in English (V-dot-O-two-max, the volume of oxygen the body can take in, deliver, and use per minute at maximum aerobic effort, expressed in mL/kg/min) and traces the *Norwegian 4 x 4* folk name to Jan Helgerud's research group.

### Metrics
- Total articles: 84
- Coverage: 84 of 87 proposed concepts written (97%)
- Articles edited since last checkpoint: 35

## 2026-05-15

### What's New
- **New article:** [Frailty Index](frailty-index.md) — how accumulated health deficits turn frailty into a measurable whole-person risk signal.
- **New article:** [Advanced Glycation End Products (AGEs)](glycation-end-products.md) — how glycation and high-heat food chemistry shape cardiometabolic risk claims without proving a longevity protocol.
- **Improved:** [Dose-Curve Antipattern (Hormesis Overdose)](hormesis-overdose.md) — clearer opening guidance on dosing stress against recovery.
- **Improved:** [Mindfulness for Cortisol Modulation](mindfulness-cortisol-modulation.md) — clearer boundaries around cortisol, stress claims, and mindfulness as stress-response training.
- **Improved:** [Biomarker Treadmill](biomarker-treadmill.md) — a clearer opening gate that separates useful testing from measurement-driven escalation.
- **Improved:** [Glucose Anxiety](glucose-anxiety.md) — a clearer opening gate that separates useful CGM experiments from food surveillance.
- **Improved:** [Epigenetic Age Testing](epigenetic-age-testing.md) — a clearer opening gate that treats biological-age reports as model outputs, not verdicts.

### Metrics
- Total articles: 80
- Coverage: 80 of 84 proposed concepts written (95%)
- Articles edited since last checkpoint: 5

## 2026-05-13

### What's New
- **New article:** [Creatine Monohydrate](creatine-monohydrate.md) — how to use a cheap supplement as a bounded training adjunct without turning it into another permanent stack item.
- **New article:** [Hearing Correction as Cognitive-Reserve Support](hearing-cognitive-reserve.md) — how treatable hearing loss can affect communication, social participation, and cognitive-health strategy without becoming a dementia-prevention overclaim.
- **Improved:** [Mediterranean Diet Pattern](mediterranean-diet-pattern.md) — redrafted with a clearer opening, tighter evidence framing, and a sharper distinction between a research-defined food pattern and Mediterranean-branded wellness shorthand.
- **Improved:** [Resistance Training for Sarcopenia Prevention](sarcopenia-resistance-training.md) — improved with a clearer opening, tighter progression language, and cleaner strength-versus-cardio framing.
- **Improved:** [Fountain-Life-Style Annual Deep Screen](fountain-deep-screen.md) — redrafted with a clearer opening, tighter prose, and a sharper distinction between governed preventive care and a premium diagnostic dashboard.
- **Improved:** [Evaluating a Longevity Clinic](longevity-clinic-evaluation.md) — improved with a clearer opening gate and tighter clinic-governance due-diligence language.
- **Improved:** [Medical Tourism for Longevity](longevity-medical-tourism.md) — redrafted with a clearer opening gate and a tighter jurisdiction-versus-quality diligence frame.

### Metrics
- Total articles: 78
- Coverage: 78 of 84 proposed concepts written (93%)
- Articles edited since last checkpoint: 5

## 2026-05-13

### What's New
- **New article:** [Photobiomodulation (Red and Near-Infrared Light)](red-nir-photobiomodulation.md) — a dose- and endpoint-specific guide to red and near-infrared light therapy that separates selected human evidence from unproved longevity claims.
- **New article:** [Metabolic Flexibility](metabolic-flexibility.md) — explains fuel switching across fasting, feeding, rest, and exercise without turning a consumer score into healthspan proof.
- **Improved:** [Evidence Tiers](evidence-tiers.md) — added a short plain-language on-ramp, cleaned front-matter spacer artifacts, and tightened the GRADE and sauna examples so the article reads more like a field-facing evidence tool.
- **Improved:** [Finnish Sauna Protocol](finnish-sauna-protocol.md) — added a short plain-language on-ramp that separates Finnish dry-sauna exposure from generic heat use and sharpened the observational-evidence boundary around sauna longevity claims.
- **Improved:** [Stack Creep](stack-creep.md) — redrafted with a clearer opening, tighter prose, and a sharper supplement-ledger method for deciding which items still earn their place.
- **Structural:** [Introduction](introduction.md), [Cognitive and Psychosocial Resilience](cognitive-psychosocial.md), [Hormetic Stress](hormetic-stress.md), [Nutritional Modulation](nutritional-modulation.md), [Physical Training](physical-training.md), and [Regenerative and Frontier](regenerative-frontier.md) landing pages now include complete links to their local entries.

### Metrics
- Total articles: 76
- Coverage: 76 of 84 proposed concepts written (90%)
- Articles edited since last checkpoint: 3 (plus 6 section landing pages improved)

## 2026-05-13

### What's New
- **Improved:** [ApoB Screening](apob-screening.md) — polished for prose quality: tightened the Context and Problem framing, cut "It is" stacks and copula-avoidance across Solution and Evidence, varied verb choice in How It Plays Out, and elevated the contraction floor throughout to match the section's clinician register.
- **Improved:** [Resting Heart Rate and HRV](resting-hr-hrv.md) — polished for prose quality: tightened the wearables-versus-physiology framing, cut a copula-avoidance and a filler adverb in Solution, broke a triple-clause composite-score sentence into a clean three-fact list, and recast the cross-reference notes as field-facing claims.
- **Improved:** [Lifestyle Theater](lifestyle-theater.md) — polished for prose quality: broke the "is not… It is…" copula-stack in the central definition, collapsed a three-sentence "may still" tricolon into a clean list, traded the stilted "makes the difference between X and Y visible" for "draws the line between," cut a buried-passive into an active construction, and elevated the contraction floor throughout.
- **Structural:** Cross-link descriptions in sixteen entries' Related Articles tables now describe what each relationship is about in the world — separate evidence tiers for prediction, screening, and outcome change; the difference between analytical performance and mortality benefit in cancer-signal testing; how light timing sets the night's available sleep windows — rather than narrating the article's editorial need for the cross-reference.

### Metrics
- Total articles: 74
- Coverage: 74 of 78 proposed concepts written (95%)
- Articles edited since last checkpoint: 3 (plus 16 articles touched by the related-notes sweep)

## 2026-05-12

### What's New
- **New article:** [Stem Cell Therapy (Allogeneic MSC, Autologous SVF)](stem-cell-therapy.md) — a sourced guide to mesenchymal stromal-cell and adipose stromal-vascular-fraction therapy that separates regulated transplantation, intra-articular knee-osteoarthritis RCT evidence, disease-specific systemic approvals, IV longevity packages, and the post-2022 US regulatory map.
- **New article:** [Aspirational Stack Theater](aspirational-stack-theater.md) — a sourced antipattern entry naming the gap between a publicly maintained longevity protocol and the lived one, with a five-part adherence audit and the Goffman front-stage / back-stage frame translated into longevity practice.
- **New article:** [Low-Dose Tadalafil (Off-Label Longevity Use)](tadalafil-longevity-use.md) — a sourced guide to daily 2.5–5 mg PDE5 inhibition that separates RCT-grade evidence in erectile dysfunction, BPH, and pulmonary arterial hypertension from the observational dementia-incidence signal, maps the contraindications and CYP3A4 interactions, and frames the off-label longevity case against clinician supervision rather than telemedicine-package marketing.
- **New article:** [Concierge Longevity Primary Care (Attia / Early Medical Pattern)](attia-concierge-care.md) — what a retainer-based longevity practice should actually buy you, the three structural failure modes to watch for, and the diligence questions a serious practice will answer in writing.
- **New article:** [Wellness-Influencer SEO Listicle](wellness-seo-listicle.md) — names the dominant longevity-content genre on the open web (the affiliate-driven, evidence-flattening, cost-and-availability-blind ranked roundup), gives the reader seven diagnostic questions to run any list-shaped longevity piece through in sixty seconds, and anchors the evidence in the FTC's health-claim substantiation framework and two decades of health-news-quality review.
- **Improved:** [Healthspan vs. Lifespan](healthspan-lifespan.md) — added inline cross-references to eight related entries (biological age, VO₂max, ApoB, evidence tiers, full-body MRI, coronary calcium scoring, resistance training, the longevity pyramid, and Lifestyle Theater) so readers can locate the surrounding map from the foundational concept, plus light prose tightening.
- **Improved:** [VO₂max](vo2max.md) — polished for prose quality: tighter problem framing, cleaner AHA-statement paragraph, contraction-floor fixes, and a less pat closer.
- **Improved:** [Zone 2 Cardio](zone-2-cardio.md) — polished for prose quality: tightened the Context and Problem framing, varied the cadence of the Forces bullets, cleaned the Solution opening, and replaced the patronizing closer with a direct imperative.

### Metrics
- Total articles: 74
- Coverage: 74 of 78 proposed concepts written (95%)
- Articles edited since last checkpoint: 3

## 2026-05-10

### What's New
- **New article:** [Hormone Replacement Therapy (Female: HRT/BHRT)](female-hrt-bhrt.md) — a sourced guide to menopause hormone therapy, evidence tiers, timing, formulation, compounded-product risk, and the boundary between symptom treatment and broad longevity claims.
- **New article:** [Testosterone Replacement Therapy (TRT)](testosterone-replacement-therapy.md) — a sourced guide to diagnosis, candidate selection, fertility, TRAVERSE-era safety evidence, prostate monitoring, FDA regulatory updates, and the boundary between replacement therapy and performance-clinic escalation.
- **New article:** [Therapeutic Plasma Exchange and Plasma Dilution](plasma-exchange-dilution.md) — a sourced guide to plasma exchange as a frontier longevity intervention, including biological-age evidence, procedural risks, young-plasma cautions, and the boundary between biomarker movement and proven healthspan outcomes.
- **New article:** [Sleep Tracking Anxiety](sleep-tracking-anxiety.md) — a sourced guide to orthosomnia, wearable sleep-score fixation, consumer sleep-technology limits, and how to use sleep trends without turning them into nightly verdicts.
- **New article:** [Blueprint Protocol (Bryan Johnson)](blueprint-bryan-johnson.md) — a sourced guide to reading Blueprint as a public n-of-1 longevity protocol, separating its transferable process discipline from supplement, clinical, frontier, and commercial layers.
- **New article:** [Glucose Anxiety](glucose-anxiety.md) — a sourced guide to using CGM data without turning normal post-meal glucose variation into food fear, spike chasing, or self-diagnosis.
- **New article:** [Continuous Glucose Monitoring (Non-Diabetic)](nondiabetic-cgm.md) — a sourced guide to short CGM experiments, OTC device boundaries, healthy glucose-range evidence, and how to avoid turning glucose traces into food verdicts.
- **New article:** [Hyperbaric Oxygen Therapy (HBOT)](hyperbaric-oxygen-therapy.md) — a sourced guide to hard-chamber oxygen protocols, mild-chamber confusion, small human RCT signals, device safety, and the gap between biomarker movement and proven longevity outcomes.
- **New article:** [Full-Body MRI Screening](full-body-mri.md) — a sourced guide to broad MRI screening, incidental-finding cascades, ACR and Choosing Wisely boundaries, high-risk surveillance exceptions, and why no radiation does not mean no harm.
- **New article:** [Peptide Therapeutics](peptide-therapeutics.md) — a sourced guide to FDA-approved peptide drugs, compounded and research-use peptides, April 2026 FDA review status, BPC-157 and CJC-1295 evidence limits, and how to avoid turning a peptide menu into stack creep.
- **New article:** [Hallmarks of Aging](aging-hallmarks.md) — a sourced mechanism map for geroscience claims that separates hallmark modulation from human healthspan evidence and flags where 2025 extensions remain proposed rather than settled.
- **New article:** [Biological Age](biological-age.md) — a sourced guide to reading biological-age scores as model outputs, separating risk prediction from healthspan proof and clarifying how Horvath, PhenoAge, GrimAge, and pace-of-aging measures differ.
- **New article:** [Pace of Aging](aging-pace.md) — a sourced guide to DunedinPACE-style rate measures, the 2025 older-adult healthspan and lifespan analysis, and the boundary between risk prediction and proof that an intervention slows human aging.
- **New article:** [Hormesis](hormesis.md) — a sourced guide to bounded adaptive stress, dose-response curves, recovery markers, and why heat, cold, fasting, exercise, and antioxidant examples still need evidence tiers and stop rules.
- **New article:** [Single-Biomarker Tunnel Vision](single-biomarker-tunnel.md) — a sourced guide to biomarker myopia, proxy failure, overscreening cascades, wearable-score anxiety, and how to keep one number from becoming the whole plan.
- **New article:** [Mechanism-Pumping](mechanism-pumping.md) — a sourced guide to keeping pathway stories, biomarker changes, and human outcome claims in separate evidence tiers.
- **New article:** [The Longevity Pyramid](longevity-pyramid.md) — a sourced guide to sequencing longevity work by evidence, risk, cost, and maturity before expensive or experimental interventions outrun the base.
- **New article:** [Biomarker Treadmill](biomarker-treadmill.md) — a sourced guide to keeping bloodwork, imaging, wearable metrics, and biological-age testing tied to clear decisions instead of open-ended measurement escalation.
- **New article:** [Caloric Restriction](caloric-restriction.md) — a sourced guide to sustained energy reduction without malnutrition, what CALERIE and rhesus-monkey studies show, and where human lifespan claims still outrun the evidence.
- **New article:** [MIND Diet Pattern](mind-diet-pattern.md) — a sourced guide to the Mediterranean-DASH cognitive-aging food pattern, what the cohort and pathology evidence suggests, and why the neutral randomized trial keeps the dementia-prevention claim bounded.
- **New article:** [Polyphenol Intake](polyphenol-intake.md) — a sourced guide to building plant-chemical diversity through foods while keeping supplement and pathway claims inside their evidence tier.
- **New article:** [Grip Strength as Mortality Biomarker](grip-strength-mortality.md) — a sourced guide to using handgrip dynamometry as a cheap functional-reserve signal without mistaking it for a whole-body aging score.
- **New article:** [Stability and Mobility Practice](stability-mobility-practice.md) — a sourced guide to training balance, joint control, gait, and usable range so cardio and strength work can stay repeatable across decades.
- **New article:** [Lp(a) Screening](lpa-screening.md) — a sourced guide to once-in-adulthood lipoprotein(a) testing as an inherited cardiovascular-risk signal that should sharpen, not replace, the broader risk map.
- **New article:** [Comprehensive Annual Bloodwork](comprehensive-annual-bloodwork.md) — a sourced guide to turning yearly preventive labs into a governed risk review without letting broad testing become biomarker theater.
- **New article:** [Cold Water Immersion](cold-water-immersion.md) — a sourced guide to using cold exposure as a bounded stressor without upgrading acute sensation or mechanism into lifespan proof.
- **New article:** [Heat Shock Proteins (HSPs)](heat-shock-proteins.md) — a sourced guide to the proteostasis mechanism behind heat and exercise claims without upgrading HSP activation into longevity proof.
- **New article:** [Exercise-Induced Hormesis](exercise-induced-hormesis.md) — a sourced guide to exercise as recoverable adaptive stress and to why high-dose antioxidant shortcuts can conflict with training adaptation.
- **New article:** [Hypoxic Conditioning](hypoxic-conditioning.md) — a sourced guide to altitude and breath-hold oxygen stress that keeps performance evidence, breathwork effects, and longevity claims in separate boxes.
- **New article:** [DEXA Body Composition](dexa-body-composition.md) — a sourced guide to using DEXA for visceral fat, lean mass, and bone density without turning the scan into another biomarker treadmill.
- **New article:** [Epigenetic Age Testing](epigenetic-age-testing.md) — a sourced guide to using methylation clocks as model-output audits without turning one biological-age score into a steering wheel.
- **New article:** [Coronary Artery Calcium Scoring (CAC)](coronary-calcium-scoring.md) — a sourced guide to using CAC as a selective cardiovascular-risk decision aid without turning a zero or positive score into the whole prevention plan.
- **New article:** [Coronary CT Angiography (CCTA)](coronary-ct-angiography.md) — a sourced guide to using CCTA for targeted coronary anatomy questions without turning the scan into routine longevity surveillance.
- **New article:** [Multi-Cancer Early Detection (MCED)](mced-screening.md) — a sourced guide to using MCED blood tests as clinician-supervised adjunct screening without replacing standard cancer screening or buying a false cancer-clearance signal.
- **New article:** [Circadian Light Hygiene](circadian-light-hygiene.md) — a sourced guide to using morning brightness, evening dimming, and dark sleep environments to give the body's clock a clearer timing signal.
- **New article:** [Sleep Consistency](sleep-consistency.md) — a sourced guide to using stable sleep-wake timing to reduce social jetlag without turning bedtime into another score to chase.
- **New article:** [Caffeine Half-Life and Adenosine](caffeine-adenosine-cycle.md) — a sourced guide to testing caffeine dose and timing without mistaking sleep onset for a clean night or a sleep score for a diagnosis.
- **New article:** [Social Connection as Longevity Intervention](social-connection-longevity.md) — a sourced guide to treating reciprocal ties and group embedding as healthspan infrastructure without pretending loneliness has a simple protocol fix.
- **New article:** [Cognitive Reserve](cognitive-reserve.md) — a sourced guide to how education, role, social contact, and cognitive demand may preserve cognitive function without becoming a brain-game prescription.
- **New article:** [Personality-Brand Capture](personality-brand-capture.md) — a sourced guide to learning from public longevity figures without copying a protocol, supplement stack, or clinical intervention beyond the evidence.
- **New article:** [Metformin and the TAME Frame](metformin-tame-frame.md) — a sourced guide to separating metformin's diabetes evidence from the still-unproven claim that it delays multiple diseases of aging.
- **New article:** [The Longevity Clinic](longevity-clinic.md) — a sourced guide to reading clinic offers as care models with evidence, regulatory, incentive, safety, and follow-up boundaries.
- **New article:** [Senolytics (Dasatinib + Quercetin, Fisetin)](senolytic-cocktails.md) — a sourced guide to dasatinib-plus-quercetin and fisetin cell-clearance protocols, their early human evidence, clinical risks, and still-unproven healthy-adult longevity claim.
- **Improved:** [Introduction](introduction.md) — replaced the scaffold with a full orientation to longevity and performance patterns, including evidence scope, medical boundaries, reader paths, and pattern-language framing.

### Metrics
- Total articles: 69
- Coverage: 69 of 78 proposed concepts written (88%)
- Articles edited since last checkpoint: 44

## 2026-05-08

### What's New
- **New article:** [Healthspan vs. Lifespan](healthspan-lifespan.md) — a sourced guide to distinguishing years alive from years lived with preserved function.
- **New article:** [Evidence Tiers](evidence-tiers.md) — a practical grading map for distinguishing human trials, observational evidence, mechanism, consensus, and disputed longevity claims.
- **New article:** [Lifestyle Theater](lifestyle-theater.md) — a sourced antipattern for recognizing when visible longevity signals displace the base behaviors that preserve function.
- **New article:** [Time-Restricted Eating](time-restricted-eating.md) — a sourced guide to daily eating windows, mixed human trial evidence, contraindications, and the boundary between fasting structure and fasting identity.
- **New article:** [Protein Intake for Sarcopenia Prevention](sarcopenia-protein-intake.md) — a sourced guide to daily and per-meal protein targets, resistance-training pairing, and medical boundaries for preserving muscle function with age.
- **New article:** [Mediterranean Diet Pattern](mediterranean-diet-pattern.md) — a sourced guide to the food-quality base behind cardiovascular, cognitive-aging, and healthy-aging claims.
- **New article:** [Fasting-Mimicking Diet](fasting-mimicking-diet.md) — a sourced guide to 5-day periodic fasting-mimicking cycles, their human biomarker evidence, commercial context, and safety boundaries.
- **New article:** [Stack Creep](stack-creep.md) — a sourced antipattern for auditing supplement accumulation before it becomes an expensive, poorly governed longevity routine.
- **New article:** [VO₂max](vo2max.md) — a sourced guide to cardiorespiratory fitness as a measured capacity, mortality-risk marker, and training target with clear testing boundaries.
- **New article:** [Zone 2 Cardio](zone-2-cardio.md) — a sourced guide to aerobic base training, lactate-threshold uncertainty, recoverable weekly dose, and the boundary between useful physiology and Zone 2 hype.
- **New article:** [VO₂max-Targeted Intervals](vo2max-targeted-intervals.md) — a sourced guide to using hard aerobic intervals to raise the cardiorespiratory ceiling while respecting recovery, injury, and safety boundaries.
- **New article:** [Resistance Training for Sarcopenia Prevention](sarcopenia-resistance-training.md) — a sourced guide to progressive loading for preserving strength, power, lean mass, bone-loading stimulus, and physical reserve with clear safety boundaries.
- **New article:** [Finnish Sauna Protocol](finnish-sauna-protocol.md) — a sourced guide to dry sauna frequency, cardiovascular evidence, observational limits, and heat-dose safety boundaries.
- **New article:** [Dose-Curve Antipattern (Hormesis Overdose)](hormesis-overdose.md) — a sourced guide to avoiding recovery-blind stress dosing across heat, cold, fasting, hypoxia, and training.
- **New article:** [ApoB Screening](apob-screening.md) — a sourced guide to using apoB as a particle-count companion to the lipid panel, with clear limits on universal screening and clinician interpretation.
- **New article:** [Resting Heart Rate and HRV](resting-hr-hrv.md) — a sourced guide to wearable-era autonomic trend signals, mortality evidence, recovery-score limits, and when the numbers need clinical context.
- **New article:** [Sleep Architecture](sleep-architecture.md) — a sourced guide to N1, N2, N3, REM, sleep-cycle timing, wearable-stage limits, and why total sleep time is necessary but incomplete.
- **New article:** [Purpose (Ikigai-class) as Longevity Factor](ikigai-longevity-factor.md) — a sourced guide to purpose as a measured longevity-adjacent factor, with mortality, dementia, physical-function, causality, and SES boundaries.
- **New article:** [Mindfulness for Cortisol Modulation](mindfulness-cortisol-modulation.md) — a sourced guide to mindfulness as stress-response training, with clear cortisol, HRV, active-comparator, safety, and longevity-claim boundaries.
- **New article:** [Rapamycin Off-Label Longevity Dosing](rapamycin-longevity-dosing.md) — a sourced guide to off-label intermittent sirolimus, its animal and human evidence, monitoring boundaries, and where the longevity claim remains unproven.
- **New article:** [GLP-1 Receptor Agonists for Longevity-Adjacent Outcomes](glp1-longevity-outcomes.md) — a sourced guide to semaglutide, tirzepatide, cardiovascular and metabolic outcome evidence, safety updates, lean-mass risk, and the limits of the healthy-adult longevity claim.
- **New article:** [Evaluating a Longevity Clinic](longevity-clinic-evaluation.md) — a sourced due-diligence checklist for checking clinic credentials, evidence claims, incentives, safety systems, and exit paths before buying a protocol.
- **New article:** [Medical Tourism for Longevity](longevity-medical-tourism.md) — a sourced map for separating cross-border access from evidence, regulation, product identity, facility governance, and continuity of care.
- **New article:** [Fountain-Life-Style Annual Deep Screen](fountain-deep-screen.md) — a sourced guide to evaluating high-cost annual longevity-clinic diagnostic bundles by component evidence, follow-up governance, and false-positive risk.
- **New article:** [Medical Tourism Quality Roulette](medical-tourism-roulette.md) — a sourced guide to avoiding cross-border frontier-care decisions where access outruns evidence, safety systems, records, and follow-up care.
- **New article:** [Rapamycin Cargo-Culting](rapamycin-cargo-culting.md) — a sourced guide to the trap of treating mouse data, expert enthusiasm, and a weekly dose as settled healthy-adult longevity medicine before monitoring and stopping rules exist.

### Metrics
- Total articles: 26
- Coverage: 26 of 78 proposed concepts written (33%)
- Articles edited since last checkpoint: 26

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- [Next: Article Map](article-map.md)
- [Previous: Introduction](introduction.md)